{"id":2259,"date":"2016-01-08T21:21:53","date_gmt":"2016-01-08T19:21:53","guid":{"rendered":"http:\/\/dralpergokce.com\/?p=2259"},"modified":"2016-07-14T16:42:12","modified_gmt":"2016-07-14T13:42:12","slug":"kok-hucreler-vucudun-tamircileri","status":"publish","type":"post","link":"https:\/\/dralpergokce.com\/en\/2016\/01\/08\/kok-hucreler-vucudun-tamircileri\/","title":{"rendered":"K\u00f6k h\u00fccreler: V\u00fccudun tamircileri"},"content":{"rendered":"<div id=\"pl-2259\"  class=\"panel-layout\" ><div id=\"pg-2259-0\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-2259-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-2259-0-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"0\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p><strong>K\u00f6k h\u00fccre nedir?<\/strong>\u00a0K\u00f6k\u00a0h\u00fccre kelimesi ba\u015fka bir h\u00fccreye farkl\u0131la\u015fma yetene\u011fi olan h\u00fccreleri tan\u0131mlak i\u00e7in kullan\u0131lan \u015femsiye terimdir.<\/p>\n<p><strong>Farklar\u0131 var m\u0131d\u0131r?\u00a0<\/strong>H\u00fccreler farkl\u0131la\u015fma yetene\u011fine g\u00f6re farkl\u0131 isimler almaktad\u0131rlar. Anne ve babam\u0131zdan gelerek insan bedenini anne karn\u0131nda olu\u015fturan en temel en yetenekli h\u00fccre ve ondan t\u00fcreyen \u00e7e\u015fitli organ ve taslaklar\u0131n\u0131 olu\u015fturan k\u00f6k h\u00fccreler bulunmaktad\u0131r. Eri\u015fkin hayat\u0131m\u0131zda bulabilece\u011fimiz k\u00f6k h\u00fccre kaynaklar\u0131 ne yaz\u0131k ki mezenkimal k\u00f6k h\u00fccreler ile s\u0131n\u0131rl\u0131d\u0131r.<\/p>\n<p>Mezenkimal k\u00f6k h\u00fccreler bir\u00e7ok dokuda bulunan ve yara onar\u0131m veya organ yenilenmesinde bulundu\u011fu ortam ve ald\u0131\u011f\u0131 \u00e7evresel sinyaller do\u011frultusunda farkl\u0131la\u015f\u0131m g\u00f6steren h\u00fccrelerdir.<\/p>\n<p><strong>G\u00f6revleri nelerdir?<\/strong>\u00a0Embriyonik\u00a0k\u00f6k\u00a0h\u00fccreleri y\u00fcksek b\u00fcy\u00fcme ve iyile\u015fme potansiyelleri nedeniyle\u00a0hakk\u0131nda\u00a0 yaz\u0131lan \u00e7izilen \u00e7ok say\u0131da bilgi dola\u015f\u0131yor olsa da etik\u00a0sorunlar nedeniyle tedavide kullan\u0131lmamaktad\u0131r. \u0130nsan v\u00fccudundaki dokular yenilenmek ve yaralar\u0131n onar\u0131m\u0131 i\u00e7in mezenkimal k\u00f6k h\u00fccreler g\u00f6revlidirler. K\u00f6k h\u00fccreler bulunduklar\u0131 ortamdaki dokulara benzeyerek (farkl\u0131la\u015farak) \u00e7o\u011fal\u0131rlar.<\/p>\n<p><strong>Eri\u015fkin\u00a0k\u00f6k\u00a0h\u00fccreleri\u00a0nelerdir?<\/strong>\u00a0Onlar\u00a0v\u00fccudun tamircileridir. Yaralanmalar\u0131n oldu\u011fu dokularda kimyasal veya enfektif hasarlar\u0131n onar\u0131m\u0131\u00a0i\u00e7in\u00a0gerekti\u011finde eyleme\u00a0ge\u00e7mek\u00a0i\u00e7in\u00a0haz\u0131r \u015fekilde\u00a0\u00e7e\u015fitlidokularda\u00a0i\u00e7inde\u00a0ya\u015f\u0131yorlar.\u00a0Bir\u00e7ok doku kendi dokusunu birebir onarmamaktad\u0131r. Mezenkimal k\u00f6k h\u00fccreler ise genelde ba\u011f dokusu ile iyile\u015fmeyi y\u00f6netirler. \u0130yile\u015fme ve onar\u0131m potansiyeli bu nedenle ba\u011f dokusunda en ba\u015far\u0131l\u0131 olmaktad\u0131r. \u0130skelet sistemi bu gruptad\u0131r.<\/p>\n<p><strong>Yeti\u015fkin\u00a0Mezenkimal k\u00f6k\u00a0h\u00fccrelerinin t\u00fcrleri nelerdir?<\/strong><\/p>\n<p>En\u00a0yayg\u0131n\u00a0hematopoetik (kan yap\u0131c\u0131)\u00a0k\u00f6k\u00a0h\u00fccre\u00a0(HSC-CD\u00a034+) bilinir.\u00a0Bu h\u00fccreler\u00a0dola\u015f\u0131mdaki\u00a0kan\u00a0veya\u00a0kemik\u00a0ili\u011finden\u00a0elde\u00a0edilirler. Kolay elde ediliyor olmalar\u0131ndan dolay\u0131 s\u0131kl\u0131kla kalp\u00a0ve\u00a0damar\u00a0uygulamalar\u0131\u00a0gibi s\u0131n\u0131rl\u0131 bir grup\u00a0hastal\u0131k tedavisinde\u00a0denenmi\u015f etkili\u00a0oldu\u011fundan tam emin olunamam\u0131\u015ft\u0131r. Yine de \"k\u00f6k\u00a0h\u00fccre\"\u00a0tedavisi olarak daha az yararl\u0131\u00a0h\u00fccreler olmas\u0131na ra\u011fmen kemik ili\u011finden toplanan kandan elde edilen h\u00fccre olarak tedavilerde kullan\u0131l\u0131rlar.\u00a0Doku\u00a0onar\u0131m\u0131\u00a0ile\u00a0ilgili olarak\u00a0yap\u0131lan ara\u015ft\u0131rmalarda en\u00a0s\u0131k\u00a0eri\u015fkin\u00a0k\u00f6k\u00a0h\u00fccre\u00a0 t\u00fcr\u00fc olarak Mezenkimal K\u00f6k\u00a0h\u00fccreler(MKH) kullan\u0131l\u0131rlar.<\/p>\n<p><strong>Ortopedik\u00a0uygulamalarda k\u00f6k h\u00fccre kullan\u0131m\u0131 nelerdir?<\/strong><\/p>\n<p>Kemik\u00a0ili\u011finden\u00a0t\u00fcretilmi\u015f\u00a0ve\u00a0ya\u011f dokusundan elde edilmi\u015f olmak \u00fczere iki ayr\u0131 kaynaktan\u00a0MKH kullanmaktay\u0131z.\u00a0Kemik\u00a0ili\u011finden t\u00fcretilmi\u015f k\u00f6k\u00a0h\u00fccrelerin\u00a0kemik\u00a0ili\u011finden\u00a0bir\u00a0i\u011fne arac\u0131l\u0131\u011f\u0131yla\u00a0al\u0131n\u0131p ayr\u0131\u015ft\u0131r\u0131lmas\u0131 ile elde edilirler.\u00a0Kemik\u00a0ili\u011fi\u00a0aspirasyonu \u00e7ok zor bir i\u015flem gibi alg\u0131lanmas\u0131na ra\u011fmen hastalar taraf\u0131ndan genelde konforlu bir i\u015flem olarak adland\u0131r\u0131l\u0131rlar.\u00a0 MKH\u2019n\u0131n ikinci\u00a0tipi\u00a0ya\u011f\u00a0dokusundan(ya\u011f)\u00a0elde\u00a0edilir.\u00a0Bu teknikte\u00a0liposuction ad\u0131 verilen ki\u015fiden ya\u011f alma s\u00fcre\u00e7leri kullan\u0131l\u0131r. Ortopedik\u00a0uygulamalar\u00a0i\u00e7in\u00a0ya\u011f\u00a0MKH'\u0131n\u00a0s\u00fcrekli olarak \u00fcretilen ya\u011f ve kemik ili\u011finden al\u0131nmas\u0131n\u0131n sebebi bundand\u0131r.<\/p>\n<p>K\u0131k\u0131rdak\u00a0tamirleri,\u00a0onar\u0131m\u0131 ya da kemik\u00a0ve\u00a0yumu\u015fak hasar ve yaralanmalar\u0131n\u0131n onar\u0131m\u0131,\u00a0kemik\u00a0ili\u011fi k\u00f6kenli MKH\u2019lardan yap\u0131lmas\u0131 k\u00f6ken benze\u015fmesinin temeline dayanmaktad\u0131r. \u0130yile\u015fmeyen bir k\u0131r\u0131\u011f\u0131n kaynamas\u0131 veya eklem dokusundaki k\u0131k\u0131rdak onar\u0131m\u0131 i\u00e7in kemik ili\u011fi bulunmaz benzerlikte bir (homolog)\u00a0kaynakt\u0131r.<\/p>\n<p>K\u0131k\u0131rdak sorunlar\u0131 ile kar\u015f\u0131la\u015f\u0131ld\u0131\u011f\u0131nda alt\u0131ndaki kemikte mikro-k\u0131r\u0131k yapma suretiyle k\u00f6k h\u00fccreler ula\u015fma iste\u011fi bu sebepten ortaya \u00e7\u0131km\u0131\u015ft\u0131r.<\/p>\n<\/div>\n<\/div><\/div><\/div><div id=\"pgc-2259-0-1\"  class=\"panel-grid-cell\" ><div id=\"panel-2259-0-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"1\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-2702\" src=\"http:\/\/dralpergokce.com\/wp-content\/uploads\/2016\/05\/kok_hucre_5-300x162.jpg\" alt=\"kok_hucre_5\" width=\"300\" height=\"162\" srcset=\"https:\/\/dralpergokce.com\/wp-content\/uploads\/2016\/05\/kok_hucre_5-300x162.jpg 300w, https:\/\/dralpergokce.com\/wp-content\/uploads\/2016\/05\/kok_hucre_5.jpg 650w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p><strong>We will call you.<\/strong><strong><br \/><\/strong><\/p>\n<div class=\"wpcf7 no-js\" id=\"wpcf7-f7588-o1\" lang=\"tr-TR\" dir=\"ltr\" data-wpcf7-id=\"7588\">\n<div class=\"screen-reader-response\">\n<p role=\"status\" aria-live=\"polite\" aria-atomic=\"true\">\n<ul><\/ul>\n<\/div>\n<form action=\"\/en\/wp-json\/wp\/v2\/posts\/2259#wpcf7-f7588-o1\" method=\"post\" class=\"wpcf7-form init\" aria-label=\"\u0130leti\u015fim Formu\" novalidate=\"novalidate\" data-status=\"init\" data-trp-original-action=\"\/en\/wp-json\/wp\/v2\/posts\/2259#wpcf7-f7588-o1\">\n<fieldset class=\"hidden-fields-container\"><input type=\"hidden\" name=\"_wpcf7\" value=\"7588\" \/><input type=\"hidden\" name=\"_wpcf7_version\" value=\"6.1.7\" \/><input type=\"hidden\" name=\"_wpcf7_locale\" value=\"tr_TR\" \/><input type=\"hidden\" name=\"_wpcf7_unit_tag\" value=\"wpcf7-f7588-o1\" \/><input type=\"hidden\" name=\"_wpcf7_container_post\" value=\"0\" \/><input type=\"hidden\" name=\"_wpcf7_posted_data_hash\" value=\"\" \/><br \/>\n<\/fieldset>\n<div class=\"row\">\n<div class=\"col-xs-12  col-md-12\">\n<p><span class=\"wpcf7-form-control-wrap\" data-name=\"your-name\"><input size=\"40\" maxlength=\"400\" class=\"wpcf7-form-control wpcf7-text wpcf7-validates-as-required\" aria-required=\"true\" aria-invalid=\"false\" placeholder=\"What is your name\" value=\"\" type=\"text\" name=\"your-name\" \/><\/span>\n\t\t<\/p>\n<\/p><\/div>\n<\/div>\n<div class=\"row\">\n<div class=\"col-xs-12  col-md-12\">\n<p><span class=\"wpcf7-form-control-wrap\" data-name=\"your-email\"><input size=\"40\" maxlength=\"400\" class=\"wpcf7-form-control wpcf7-email wpcf7-validates-as-required wpcf7-text wpcf7-validates-as-email\" aria-required=\"true\" aria-invalid=\"false\" placeholder=\"Your email\" value=\"\" type=\"email\" name=\"your-email\" \/><\/span>\n\t\t<\/p>\n<\/p><\/div>\n<div class=\"col-xs-12  col-md-12\">\n<p><span class=\"wpcf7-form-control-wrap\" data-name=\"your-phone\"><input size=\"40\" maxlength=\"400\" class=\"wpcf7-form-control wpcf7-tel wpcf7-validates-as-required wpcf7-text wpcf7-validates-as-tel\" aria-required=\"true\" aria-invalid=\"false\" placeholder=\"Your phone number\" value=\"\" type=\"tel\" name=\"your-phone\" \/><\/span>\n\t\t<\/p>\n<\/p><\/div>\n<\/div>\n<div class=\"row\">\n<div class=\"col-xs-12  col-md-12\">\n<p><span class=\"wpcf7-form-control-wrap\" data-name=\"your-subject\"><input size=\"40\" maxlength=\"400\" class=\"wpcf7-form-control wpcf7-text\" aria-invalid=\"false\" placeholder=\"Treatment of Interest\" value=\"\" type=\"text\" name=\"your-subject\" \/><\/span>\n\t\t<\/p>\n<\/p><\/div>\n<div class=\"col-xs-12\">\n<p><span class=\"wpcf7-form-control-wrap\" data-name=\"your-message\"><textarea cols=\"40\" rows=\"10\" maxlength=\"2000\" class=\"wpcf7-form-control wpcf7-textarea\" aria-invalid=\"false\" placeholder=\"Your message\" name=\"your-message\"><\/textarea><\/span>\n\t\t<\/p>\n<div class=\"g-recaptcha\" data-sitekey=\"6LeGAlQUAAAAALAY5xo2b0Wn8aaOun47YMwcq0MF\">\n\t\t<\/div>\n<p><input class=\"wpcf7-form-control wpcf7-submit has-spinner btn btn-primary\" type=\"submit\" value=\"Send Message\" \/>\n\t\t<\/p>\n<\/p><\/div>\n<\/div>\n<div class=\"wpcf7-response-output\" aria-hidden=\"true\"><\/div>\n<input type=\"hidden\" name=\"trp-form-language\" value=\"en\"\/><\/form>\n<\/div>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>K\u00f6k h\u00fccre nedir?\u00a0K\u00f6k\u00a0h\u00fccre kelimesi ba\u015fka bir h\u00fccreye farkl\u0131la\u015fma yetene\u011fi olan h\u00fccreleri tan\u0131mlak i\u00e7in kullan\u0131lan \u015femsiye terimdir.Farklar\u0131 var m\u0131d\u0131r?\u00a0H\u00fccreler farkl\u0131la\u015fma yetene\u011fine g\u00f6re farkl\u0131 isimler almaktad\u0131rlar. Anne ve babam\u0131zdan gelerek insan bedenini &hellip;<\/p>","protected":false},"author":1,"featured_media":2261,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[46],"tags":[83,49],"class_list":["post-2259","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ameliyatsiz-tedaviler","tag-kok-hucre","tag-prp"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>K\u00f6k h\u00fccreler: V\u00fccudun tamircileri - Prof. Dr. Alper G\u00f6k\u00e7e<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/dralpergokce.com\/en\/2016\/01\/08\/kok-hucreler-vucudun-tamircileri\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"K\u00f6k h\u00fccreler: V\u00fccudun tamircileri - Prof. Dr. Alper G\u00f6k\u00e7e\" \/>\n<meta property=\"og:description\" content=\"K\u00f6k h\u00fccre nedir?\u00a0K\u00f6k\u00a0h\u00fccre kelimesi ba\u015fka bir h\u00fccreye farkl\u0131la\u015fma yetene\u011fi olan h\u00fccreleri tan\u0131mlak i\u00e7in kullan\u0131lan \u015femsiye terimdir.Farklar\u0131 var m\u0131d\u0131r?\u00a0H\u00fccreler farkl\u0131la\u015fma yetene\u011fine g\u00f6re farkl\u0131 isimler almaktad\u0131rlar. 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